It’s safe to say that most people would prefer to slow down the physical signs of aging, particularly on their faces – and the proof is in the numbers. In 2018, the global anti-aging market was estimated to be worth around $50.2 billion U.S. dollars. Now that's a lot of skin cream and Botox. And those numbers are only increasing: by 2027, the anti-aging product industry is projected to be worth $83.2 billion U.S. dollars.
Of course, a large portion of sales are going to anti-aging creams and serums; however, there's been an increase in soft-tissues cosmetic procedures like Botox and filler treatments. A report from the American Society of Plastic Surgeons from 2018 reported around 7.4 million injections of botulinum toxin (Botox) and 2.6 million dermal filler injections we used that year.
In America alone, Botox and fillers ranked the second most popular, minimally-invasive cosmetic procedures. But why are they so popular? Due to their invasiveness, they're more effective than anti-aging creams. However, that comes at a potentially risky and painful price.
Botox's side effects include bruising and swelling at the injection site, fever, chills, and headaches. Some side effects are specific to the area of injection and include drooping eyelids, excessive tearing, and uneven eyebrows and other facial muscles. More importantly, research on the long-term side effects of Botox and fillers is limited. There are immediate results, yes; however, there's an unclear understanding of what Botox and fillers do to the body in the long-term.
Aside from health concerns, Botox and fillers can quickly add up financially, too. The most common Botox and filler treatments cost hundreds of dollars per session. Women and men around the world are risking their health and money to look youthful, but what they don't realize is there's non-invasive alternatives to these procedures, including light therapy.
Aside from light therapy’s plethora of benefits for the human body, it is an amazing anti-aging alternative for those looking for non-invasive and natural anti-aging results. Light therapy reduces fine lines and wrinkles, but goes beyond just skin deep.
While Botox and fillers work to cover the symptoms of aging skin, light therapy solves the problem at a cellular level. As we age, our body’s collagen production decreases, leaving our skin less plump and full. However, through light therapy, you’re actually stimulating collagen production beneath the skin to receive natural and similar results to Botox and fillers.
Light therapy works by delivering wavelengths of red and near-infrared light to our skin and cells. Red light enhances our cellular function, stimulating the cell's mitochondria to produce ATP (adenosine triphosphate) energy. This boost of cell energy promotes collagen and elastin production, bringing the plumpness back into your skin.
A 2014 study found that users of red light therapy experienced significantly improved skin complexion and increased collagen. Angela Lamb, M.D. and associate professor of the Department of Dermatology at the Icahn School of Medicine at Mount Sinai Hospital in New York City, stated that "Science shows that red light therapy protects existing collagen and boosts new production. Plus, it helps with texture, tone, pore size, and wrinkles."
However, there are more benefits to red light therapy than natural collagen production. Light therapy also aids in diminishing fine lines and wrinkles, reduces scarring, fights acne, treats inflammation, and aids in muscle recovery.
The proof is in the research, and study after study has shown the same results: red light therapy works for anti-aging. Rhonda Klein, M.D., a board-certified dermatologist in Connecticut, said that “Realistically, you can expect RLT to improve your skin’s tone and texture. We know that it soothes inflammation, improves mild acne, and proactively treats fine lines and wrinkles, in addition to other benefits.”
Lunas’ red light therapy devices are both MDA and FDA-approved, assuring you receive the highest quality of red light treatments available on the market, which is essential in receiving the best, most efficacious results.
Dr. Claudia Aguirre which has a Ph.D. in neuroscience from USC and travels the world lecturing on a broad range of topics from neuroscience to skin care has been researching the power of the skin and its connection with the brain.
The skin is highly innervated and intricately connected to the brain and central nervous system, just as other sensory organs are. Dr. Claudia Aguirre is discovering that the skin has a lot of neuro potential, or neuroplasticity, that has gone unrecognized. For example, just as our eyes have receptors that transduce light photons into signals to the brain that we process as vision, we’re discovering that our skin also has light receptors. Although we don’t yet know how they work, we speculate that they might be signaling the brain to make systemic changes that affect the full nervous system. Similarly, olfactory receptors in the hair follicles, just as we do in the nose.
Another example is touch, for which our skin is the primary sense organ. Skin is also our largest organ, which gives us a clue as to how important touch is. Different receptors in the skin can tell us not only whether what we touch is hot or cold, rough or smooth. Skin can even sense the intention behind the touch. A gentle touch feels much different than an aggressive one. We can tell whether the person giving us a massage is paying attention or whether they’re distracted. Moreover, different kinds of touch elicit different biochemical and hormonal responses, which have systemic results. A hug or kiss stimulates the release of oxytocin, the bonding hormone, through the bloodstream, while a punch or shove will release adrenaline and cortisol. All of these capabilities are what we say by the hidden brain in the skin.
The skin is connected to the nervous system; it’s connected to the endocrine system. The skin is impacted by our emotional states and, conversely, our skin can impact how we feel about ourselves. Cultural stress and anxiety can trigger or aggravate many skin conditions—from acne to eczema to herpes, psoriasis, and rosacea. Conversely, a disfiguring skin condition can trigger stress, anxiety, depression, and even suicide. Chronic, generalized anxiety can create chronic inflammation and exacerbate inflammatory skin conditions, such as the ones mentioned previously. Chronic stress can result in chronic anxiety, hypervigilance, poor sleep, and a whole cascade of effects resulting in a constant breakdown of tissues and organs, including the skin. There’s a whole new field of medicine being developed called psychodermatology, which is the study and treatment of the psychological component of skin conditions. Better understanding of the neuropotential of skin also opens the possibility of whole new avenues of treatment with light therapy for many of our chronic conditions.
In Kaiyan Medical we have understood that neuroscience should absolutely be part of the conversation about skincare and beauty because the brain and the skin are intimately connected. Skincare is important not only for the skin, but also the brain. That's why we keep developing light therapy devices for skin and brain. In Kaiyan we always recommend to listen for all the little signs that your skin tells you that you tend to ignore. You get a rash, and you brush it off: “Maybe it’s just dry out. Maybe I need to switch creams.” But if it occurs repeatedly, you need to look more closely and ask, “What could my skin be trying to tell me?” Are you repressing emotions? Is there a relationship issue you’re avoiding? Is there some other life circumstance that’s “gotten under your skin”? The body has a wisdom we should listen to.
We’ve all been in the search to help us achieve perfect skin. But is it just a dream, or can it really be achieved? It looks like having light shined on your face may be the most important part of your skin routine.
Red light’s anti-inflammatory and collagen-building effects on the skin have been documented for years, showing its healing abilities. However, light therapy is branching out, including other light spectrums such as green, blue, purple, and amber, for different healing abilities.
Ellen Marmur, a New York dermatologist, said, It has just enough variety that people stay excited to use it.” While many at-home devices are small and require multiple treatments to cover the entire face, masks help solve this issue.
“It makes people feel good, like they’re taking care of themselves,” Dr. Marmur said. “You can treat your skin while doing other things, so it’s easier to form the habit of doing it every day.”
LED therapy, known as photobiomodulation, can alter biological matter using varying wavelengths of light.
Jared Jagdeo, associate professor of dermatology and director of the Center for Phototherapy, SUNY Downstate Health Science University, studies LED therapy. “You can alter the skin through photo-damaging with lasers, or photobiomodulation, which is a much more gentle way of changing the way the skin functions,” he said.
When asked why red light works particularly well with skin, he said, “There’s a specific receptor in the mitochondria of the skin cells that red light specifically acts upon. And that’s why red light is an ideal wavelength for changing the way the skin functions.”
Red light can pass through the skin, deeply entering tissue and stimulating the cell’s mitochondria, which results in anti-inflammation and the skin’s rejuvenation. Collagen is also produced in the dermis, smoothing out wrinkles and plumping the skin.
While blue light doesn’t penetrate deeply into the skin, it kills acne-causing bacteria on the skin’s surface. Green light, on the other hand, focuses on melanocytes, reducing excess melanin production.
Eye safety is a valid concern, particularly because earlier this year Neutrogena recalled its LED mask over fears that it could cause eye injuries.
Brain S. Biesman, assistant clinical professor of ophthalmology, dermatology, and ENT at Vanderbilt University Medical Center in Nashville, states that most red light therapy devices aren’t powerful enough to cause eye damage. “Just normal blinking and eye movements should be sufficient to protect the eyes,” he said. “But never stare at a bright light source.”
More Thoughts
“As far as the F.D.A. is concerned, if I use CO2 laser resurfacing, it better work because of the amount of risk involved,” said Suzanne Kilmer, a clinical professor of dermatology at the UC Davis School of Medicine in Sacramento and director of the Laser and Skin Surgery Medical Group.
“Compare that to a home device,” Dr. Kilmer said. “If it doesn’t kill you, blind you or make things much worse, it’s probably going to get approved. So it’s actually more incumbent upon the people selling home devices to show efficacy. You have to trust the people who are selling them.”
“LED is real, but it’s probably not optimized yet,” Dr. Kilmer said.
With light therapy, various factors help determine the amount of light your skin needs: the light’s strength, the distance from the skin, the length of time the device is used on the skin, and the natural color of your skin.
“Some of these lights on the market are very weak, and they may not have enough energy output to actually have a biological effect,” Dr. Jagdeo said. “Imagine a glow stick. It produces a color. But you could shine it on your face all day, and it’s not going to change the way your skin works.”
Moreover, the medical community hasn’t determined the standardized dose for treating skin conditions such as hyperpigmentation and acne at home. Dr. Marmur chose her MMSphere dosing on Blu-U, an in-office blue light typically used as an alternative therapy for precancerous lesions.
“Consistent Sphere treatment for seven weeks will equal the energy given in the office with the Blu-U,” she said.
Another device, the Dr. Dennis Gross DRx SpectraLite FaceWare Pro, $435, releases red and blue light in a mask format, with each session lasting only three minutes. The mask’s LEDs are in contact with the skin, which may be a more effective treatment.
Dr. Jagdeo said, “This is a tremendously undertapped area in medicine. But LED light therapy is going to revolutionize the way home medical treatment is delivered for skin care over the next 10 to 15 years.”
If you’re considering developing your own LED facial mask, at Kayian Medical, our team of experts knows what they’re doing. We developed the Aduro mask, the top facial mask in the beauty industry with celebrities such as Julia Robert fans of the Aduro Mask. For more information, visit https://www.aduroled.com/.
Skincare doesn’t just affect the way you look. It also plays a huge role in your overall health — from body temperature to hormone regulation to your immune system. If you’re into skincare as much as we are, one of the many ways that can help you keep your skin healthy is red light therapy. In this article, we’ll take a deep dive into why you should take care of your skin, and we’ll also discuss how red light therapy devices can help you achieve your skin goals.
Are you ready? Let’s go straight into it.
As the largest organ in our body, your skin is your body’s first defense line to bacteria, germs, viruses, etc. It’s a vital part of the immune system and some processes in your body, such as temperature control, blood circulation, and hormone production.
Main Functions of the Skin
Let’s take a look at the skin's main functions to help you understand how essential it is for you to take care of this vital organ.
1. Defense and Immunity
The skin is an active immune organ, and it serves as our physical barrier from the dangers of the environment. It helps protect our bodies from diseases, germs, viruses, dirt, UV radiation, and potential thermal and physical injuries. It also helps detect and fight off infection, toxins, allergens, hazardous substances, and carcinogens.
2. Temperature Regulation
Aside from protecting us from extreme cold or heat, the skin also helps prevent moisture loss, keeping us from being dehydrated.
3. Sense of touch
The skin has a somatosensory system that is composed of touch receptors and nerve endings. This system is responsible for the sensations we feel, including pain, pressure, vibrations, smoothness, roughness, heat, cold, tickle, itch, and more.
4. Storage and Production of Vitamin D
Your body also uses your skin's deeper layers to store metabolic products, fat, and water. The skin is also responsible for producing vitamin D, supplied in the body when the skin gets enough sunlight exposure.
5. Beauty
Need we say more? Your skin plays a huge part in your appearance. Of course, when your skin is healthy, you also look glowing, radiant, and definitely more attractive.
Before we proceed with the “how,” let’s first define what red light therapy is. Red light therapy is a non-invasive treatment option for different kinds of medical conditions. It is also used for health improvement and various aesthetic procedures.
Decades ago, red light therapy machines were only available in clinics, high-end salons, and spas. Nowadays, red light therapy devices can be bought and used by anyone. In fact, you can do red light therapy at the comfort of your home and incorporate it into your skincare routine.
Red light therapy works by delivering wavelengths of red and near-infrared (NIR) light to our cells and skin. Besides helping enhance cellular function, red light therapy also helps stimulate the mitochondria and produce ATP (adenosine triphosphate) energy. This treatment option usually takes only about 10 minutes per session.
Our skin relies on millions of cells to be able to perform its functions. When our cells experience homeostasis or a state of balance, our skin and body perform (and look) better. And as mentioned above, red and NIR light enhances cellular function while also preventing inflammation and oxidative stress. Red light therapy helps make your skin look and feel softer, smoother, and healthier.
Besides, red light therapy also helps damaged tissues heal and regenerate faster. It also has anti-inflammatory benefits, potentially increasing blood flow to damaged and inflamed tissues and reducing oxidative stress.
Skincare is self-care, as keeping your skin healthy also produces multiple benefits to your health. Thankfully, aside from proper hygiene, regular exercise, a balanced diet, and an established skincare routine, red light therapy can also improve your overall skin health.
For more information about red light therapy or to view our catalog of red therapy devices, click here.
https://www.hse.gov.uk/skin/professional/causes/structure.htm
As humans, we are made of energy and fueled by light. While nutrition and exercise play a role in our well-being and health, light plays a crucial role in us functioning optimally. New and groundbreaking research is unearthing a new understanding of how our cells function and the evidence points to the power of light.
Through technological advancements in science, it’s discovered that our bodies operate similar to a battery. Wavelengths of light give us power, while our overall health determines our ability to receive and maintain the energy from light. And this is where light therapy comes into the equation.
Science has proven that our bodies interact with specific wavelengths that benefit our bodies in various ways.
Red light therapy devices, such as light therapy masks, shine red and near-infrared light onto the skin, stimulating the production of adenosine triphosphate (ATP) within the mitochondria. By stimulating ATP, damaged cells heal, and new cells are produced faster than normal. But we’ll talk more about that in-depth a little later.
Red light therapy comprises both red light and infrared wavelengths, penetrating through the skin’s layers, right into the cells. Red light wavelengths boost collagen and elastin and improve cell communication. It penetrates superficially and helps aid various skin conditions.
Near-infrared wavelengths stimulate healing, increase mitochondrial function, and improve blood flow and tissue oxygenation. Near-infrared wavelengths penetrate deeply into the body.
At the core of your body’s healing capabilities are the mitochondria. The mitochondria play a vital role in your internal organs and tissue, including the liver, skin, heart, and muscles. It’s in charge of the body’s energy supply via ATP (adenosine triphosphate).
With both working together, they provide energy to our body and maintain the cell cycle and growth. This is why you’ll often hear the mitochondria referred to as the “powerhouse of the cell.”
Here's how the mitochondria is affected by red light:
Interestingly, our body weight is made of 70% water, with 99% of our bodies' molecules also made of water, making it a powerful component in red light therapy treatment.
Research by Prof Gerald Pollock of the University of Washington proved that water adjacent to a cell is structured water, also known as EZ water. This specific water forms a separation of charge, functioning in the body as positive and negative poles - similar to a battery.
While we’ve been talking about red light therapy, what does it actually mean? Typically, “red light therapy” refers to natural light treatments which deliver red and near-infrared wavelengths as natural sunlight using LEDs or cold lasers.
While you may think red light therapy includes all colors of light, it doesn’t. The term doesn’t include blue or white light, and it isn’t equivalent to full-spectrum light. Red light therapy doesn’t rely on heat, differentiating it from other light-based treatments such as infrared saunas and heat therapy.
Red light therapy is also known as RLT, photobiomodulation (PBM), phototherapy, LED therapy, LED light therapy, infrared therapy, low-level laser therapy, or low-level light therapy (LLLT).
As stated before, red light therapy works to heal the entire body and functions on multiple levels.
Red light therapy affects the body in multiple ways, including bodily systems:
Fascia
Fascia is the thin casing of connective tissue that surrounds virtually every organ, muscle, nerve fiber, blood vessel, and bone in place. While it performs as an internal structure for your body, the fascia also contains nerves, making it almost as sensitive as skin.
The fascia may look like a layer of tissue; however, it’s made up of interwoven layers of collagen and elastin fibers. The fascia is overlooked, yet over recent years, it has been the key to understanding how changes in one area of our body affect others. Red light therapy works to improve communication within the fascia network.
Gut-Brain Axis
The gut-brain axis connects the emotional and cognitive centers of the brain with peripheral intestinal functions. Recent research discovered the importance of gut microbiota concerning these interactions.
Red light therapy can positively influence mood and neuropsychological issues by the following:
Immune System
Red and near-infrared light penetrate through the skin into the cells, which results in low-dose metabolic stress that strengthens the cells’ anti-inflammatory and natural defense systems. In turn, the body becomes resilient to infections.
Safe and low exposure to red light therapy improves the body’s response to external viruses and bacteria. Red light therapy can influence the immune response in the following ways:
Circulatory System
Red light therapy is scientifically proven to increase the micro-circulation of blood and support the circulatory system as a whole by stimulating the development of new capillaries which carry oxygen throughout the body.
Proper oxygen supply and flow are essential for the proliferation of cells, protein synthesis, tissue restoration, inflammatory response, and angiogenesis. In addition, circulation is also responsible for waste elimination, specifically degenerated cells.
Nervous System
The nervous system includes the brain, spinal cord, neurons, and neural support cells, which is your body’s command center. It controls your movements, automatic responses, and other body systems such as digestion and breathing.
Red light therapy affects the nervous system in the following ways:
For all forms of nerve damage, red light therapy offers non-pharmaceutical treatment options.
Stem Cells
Red light therapy shows impressive results regarding stem cell growth, maximizing the potential of stem cell implantation for various medical needs. Therefore, red light therapy may show positive results after surgery to stimulate stem cells which repair tissues and organs.
In studies, red light therapy has proven to stimulate mesenchymal stem cells in bone marrow, enhancing their ability to reach the brain. This research shows the possibilities of using red light therapy to heal degenerative conditions, including Alzheimer’s, Parkinson’s disease, and dementia.
It’s clear red light therapy provides multilevel treatment to the body, becoming a popular natural and holistic option for both professionals and consumers, but where did it come from?
Light therapy technology isn’t new; it’s been around for decades as NASA experimented with red light therapy during the 1980s and 1990s. Over the past 10-20 years, red light therapy reached a breakthrough in LED lighting technology, allowing the production of safe and affordable clinical and at-home devices.
In 2016, Kaiyan Medical became the first leading manufacturer of red light therapy of affordable FDA-approved and MDASAP-approved light therapy devices.
We mentioned red light therapy being a holistic treatment option, but what does that mean. Holistic medicine is a full-body approach to healthcare. By focusing on the body, mind, and soul, the body receives the full support and care it needs to function optimally.
Principles of Holistic Medicine
Holistic medicine is based on the following principles:
The purpose of treatment is to identify the underlying cause of the disease, rather than treating only the symptoms.
While there are endless benefits the body receives from red light therapy, here are the six main benefits.
Photobiomodulation, in other words, red light therapy, has proven effective against carpal tunnel syndrome, mucositis, neck pain, menstrual cramps, temporomandibular joint pain, and neuropathic pain from amputation. It also significantly reduces the pain of hypersensitivity while improving sensorimotor function.
These improvements come after anti-inflammatory cells populate the injured area, providing long-lasting pain relief. In addition, it’s also been shown to provide effective relief by affecting the following:
Red light therapy has proven to be highly effective in rapidly treating wounds from burns, scars, bedsores, ulcers, surgery incisions, and diabetic neuropathy.
NASA strongly supports this claim as this technology was used in treating wounds. Red and near-infrared light proves effective in all four phases of the wound-healing process:
These processes are regulated by various factors connected via nitric oxide (NO) signaling release, adjusted by light energy.
An issue the body encounters when trying to heal a wound is low oxygen flow, and red light increases the flow of oxygen, speeding up the natural healing process. By reducing inflammation and increasing oxygenation of the wounded area, blood vessels can form, rapidly repairing the area, lessening pain and scarring.
By reducing pain, red light therapy eliminates the reliant on pharmaceutical painkillers during the healing process.
The human body receives energy on the cellular level, maintaining communication between organs and ensuring disease resistance.
A strong immune system works to protect the body from harmful bacteria and viruses at all times. With red light therapy, the body receives a boost of support as it releases nitric oxide and melatonin, two components involved in DNA repair and antimicrobial.
This process is called hormesis. Red and near-infrared wavelengths penetrate through the skin into the cells, causing mild metabolic stress, which stimulates cells to activate their anti-inflammatory and antioxidant response.
With the support of red light therapy, the body is better prepared to fight infections. Numerous studies have proven red light therapy to have the following effects on the immune system:
Inflammation in the body can be acute and topical (short-term, resulting from sprains, infections, and accidents) or chronic and general (long-term, caused by ongoing conditions).
Acute inflammation is a healthy bodily response; however, chronic and general inflammation can negatively impact long-term health.
As of today, the current treatment for inflammation is NSAID or steroid drugs, both having a detrimental effect on the healing process and long-term health. Red light therapy stimulates the body to activate its natural healing mechanism, reducing the health risks of long-term drug use.
Red light therapy decreases the number of inflammatory cells, increases fibroblast proliferation (cells that synthesize collagen and other matrix macromolecules), stimulates angiogenesis (creation of new blood vessels), and activates the body’s anti-inflammatory, antioxidant response.
The following conditions are connected with chronic and acute inflammation, all proving promising results with red light therapy treatment:
Red light therapy is extremely popular in competitive sports and performance. It offers natural and non-pharmaceutical treatment, which applies to many areas of the body.
Aside from the overwhelming benefits on overall health, red light therapy encourages muscles growth and repair by stimulating the production of ATP, which aids in faster recovery and better performance.
Red light therapy used before training prepares and strengthens the body while aiding muscle recovery after training.
Here are the scientifically documented effects of red light therapy:
Seasonal affective disorder (SAD) is a form of depressions, impacting 5% of Americans, specifically during the winter when there’s less natural sunlight. SAD is also known as seasonal depression or winter blues.
Many people treat SAD symptoms via bright white light treatment, mimicking the sun’s light daily. However, researchers recommend natural light treatment, like red light therapy, to help with light deficiency. Over recent years, physicians recommend red light therapy alongside psychotherapy and medication.
While many people are using red light therapy devices for at-home treatment, red light therapy systems are found in many clinical and professional settings:
Skincare Professionals: Red light therapy is a popular skincare treatment among Hollywood celebrities, including Kourtney Kardashian, Julia Roberts, and Emma Stone. Leading skincare professionals like dermatologists and aestheticians use red light therapy to help promote collagen production, reduce wrinkles, and treat skin conditions.
Health Practitioners: Health practitioners from all specialties are incorporating red light therapy into their practice. Dentists use it to reduce inflammation, physicians for mental health conditions, and oncologists for cancer side effects.
Natural Health Experts: Leading voices in the health and wellness industry such as Dr. Sarah Ballantyne, Ben Greenfield, and Dave Asprey strongly support the use of red light therapy. Paleo and Keto health experts like Robb Wolf, Mark Sisson, Luke Story, and Dr. Anthony Gustin also support red light therapy.
Sports Medicine Pros: The National Sports Association of Sports Medicine (NASM) adopted red light therapy to treat sports injuries. Top trainers and doctors, including Dr. Troy Van Biezen and Dr. Ara Suppiah, use red light therapy to heal their athletes.
Elite Pro Athletes: Professional athletes worldwide, including NFL stars like Patrick Peterson, UFC champion Anthony Pettis, and gold medal gymnast Sanne Weavers use red light therapy to enhance performance and quicken recovery.
Fitness & Training: World-renown fitness trainers, including Lacey Stone and Jorge Cruise, use red light therapy to enhance athletic performance and muscle recovery.
Supportive Cancer Care: The Multinational Association of Supportive Care in Cancer (MASCC) recommends the treatment of red light therapy for oral mucositis (OM), a common symptom of cancer treatment.
Klepeis N., Nelson W., Ott W., Robinson J., Tsang A., Switzer P., Behar J., Hern S., Engelmann W. “The National Human Activity Pattern Survey (NHAPS): a resource for assessing exposure to environmental pollutants”. Journal of Exposure Analysis and Environmental Epidemiology 2001.
Hamblin M. “Mechanisms and applications of the anti-inflammatory effects of photobiomodulation.” AIMS Biophys. 2017.
LED Lights Used in Plant Growth Experiments for Deep Space Missions. NASA.
Gál P, Stausholm MB, et al. Should open excisions and sutured incisions be treated differently? A review and meta-analysis of animal wound models following low-level laser therapy. Lasers in Medical Science. 2018 Aug.
John Foley, David B Vasily, et al. 830 nm light-emitting diode (led) phototherapy significantly reduced return-to-play in injured university athletes: a pilot study. Laser Therapy. 2016 Mar.
Kim HK, Choi JH. Effects of radiofrequency, electroacupuncture, and low-level laser therapy on the wrinkles and moisture content of the forehead, eyes, and cheek. Journal of Physical Therapy Science. 2017 February.
Wunsch A and Matuschka K. A Controlled Trial to Determine the Efficacy of Red and Near-Infrared Light Treatment in Patient Satisfaction, Reduction of Fine Lines, Wrinkles, Skin Roughness, and Intradermal Collagen Density Increase. Photomedicine and Laser Surgery. Feb 2014.
Barolet D, Roberge CJ, et al. Regulation of skin collagen metabolism in vitro using a pulsed 660 nm LED light source: clinical correlation with a single-blinded study. Journal of Investigative Dermatology. 2009 December.
Morita T., Tokura H. “ Effects of lights of different color temperature on the nocturnal changes in core temperature and melatonin in humans” Journal of Physiological Anthropology. 1996, Sept.
Naeser M., Zafonte R, Krengel MH, Martin PI, Frazier J, Hamblin MR, Knight JA, Meehan WP, Baker EH. “Significant improvements in cognitive performance post-transcranial, red/near-infrared light-emitting diode treatments in chronic, mild traumatic brain injury: open-protocol study” Journal of Neurotrauma. 2014, June.
Liu KH, Liu D, et al. “Comparative effectiveness of low-level laser therapy for adult androgenic alopecia: a system review and meta-analysis of randomized controlled trials.” Lasers in Medical Science. 2019 Aug.
Gupta AK, Mays RR, et al. “Efficacy of non-surgical treatments for androgenetic alopecia: a systematic review and network meta-analysis.” JEADV. 2018 Dec.
Afifi L, Maranda EL, et al. “Low-level laser therapy as a treatment for androgenetic alopecia.” Lasers in Surgery and Medicine. 2017 Jan.
Hofling DB, Chavantes MC, et al. Low-level laser in the treatment of patients with hypothyroidism induced by chronic autoimmune thyroiditis: a randomized, placebo-controlled clinical trial. Lasers in Surgery and Medicine. May 2013.
Hofling DB, Chavantes MC, et al. Assessment of the effects of low-level laser therapy on the thyroid vascularization of patients with autoimmune hypothyroidism by color Doppler ultrasound. ISRN Endocrinology. 2012.
Hofling DB, Chavantes MC, et al. Low-level laser therapy in chronic autoimmune thyroiditis: a pilot study. Lasers in Surgery and Medicine. 2010 Aug.
Vladimirovich Moskvin S., Ivanovich Apolikhin O. Effectiveness of low level laser therapy for treating male infertility. Biomedicine (Taipei). 2018 June.
Ban Frangez H., Frangez I., Verdenik I., Jansa V., Virant Klun I. Photobiomodulation with light-emitting diodes improves sperm motility in men with asthenozoospermia. Laser in Medical Science, 2015 Jan.
Salman Yazdi, R., Bakhshi, S., Jannat Alipoor, F. et al. Effect of 830-nm diode laser irradiation on human sperm motility. Lasers Med Sci. 2014.
Chow KW, Preece D, Burns MW. Effect of red light on optically trapped spermatozoa. Biomedical Optics Express. 2017 Aug.
Preece D., Chow KW, Gomez-Godinez V., Gustafson K., et al. Red light improves spermatozoa motility and does not induce oxidative DNA damage. Scientific Reports. 2017 Apr.
American Psychiatric Association
Cassano P, Petrie SR, et al. Transcranial Photobiomodulation for the Treatment of Major Depressive Disorder. The ELATED-2 Pilot Trial. Photomedicine and Laser Surgery. 2018 October.
Barrett DW, et al. Transcranial infrared laser stimulation produces beneficial cognitive and emotional effects in humans. 2013 Jan.
Blanco NJ, Maddox WT, Gonzalez-Lima F. Improving executive function using transcranial infrared laser stimulation. Journal of Neuropsychology. 2017 Mar.
Paolillo FR, Borghi-Silva A, et al. New treatment of cellulite with infrared-LED illumination applied during high-intensity treadmill training. J Cosmet Laser Ther. 2011 Aug;13(4):166-71.
Caruso-Davis MK, Guillot TS, Podichetty VK, Mashtalir N, Dhurandhar NV, Dubuisson O, Yu Y. Efficacy of low-level laser therapy for body contouring and spot fat reduction. Obes Surg. 2011. Jun;21(6):722-9.
Jackson RF, Dedo DD, Roche GC, et al. Low-level laser therapy as a non-invasive approach for body contouring: a randomized, controlled study. Lasers in Surgery and Medicine. Dec 2009;41(10):99-809.
McRae E and Boris J. Independent evaluation of low-level laser therapy at 635 nm for non-invasive body contouring of the waist, hips, and thighs. Lasers in Surgery and Medicine. Jan 2013.
Avci P, Gupta A, et al. Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring. Seminars in Cutaneous Medicine and Surgery. Mar 2013; 32(1): 41-52.
