Alzheimer’s is a very complex disease, and one that is still undergoing significant research – there’s still a lot we still don’t understand about how and why this disease happens.
We know that Alzheimer's is a neurodegenerative disease that starts slowly and progressively worsens in most cases, and the actual memory loss and cognitive issues experienced we refer to as dementia; Alzheimer's is the physical disease that causes dementia to develop. When a person is diagnosed with Alzheimer's, the connections between their nerve cells within the brain are damaged and eventually entirely lost.
What causes the connections between the nerves to disappear is protein. Protein builds up with patients with Alzheimer's, specifically within the brain, which then causes abnormal structures we call "plaques" and "tangles." The lost connection inevitably leads to the complete death of the nerve cell, leading to lost brain tissue.
But, in recent years, studies have shown that there could be a way to improve and lessen the symptoms of dementia caused by Alzheimer’s. And it starts with light therapy.
You may have heard about light therapy, but didn’t think much of it with respect to degenerative diseases like Alzheimer’s. Well, think again. Light therapy is a non-invasive, non-pharmaceutical treatment for the body and mind. It targets the pathology at the cellular level, contributing to ATP stimulation and increasing and improving cell reproduction. Essentially, it can help with providing better and stronger cells to the body, thus resulting in a stronger organism and overall improved health.
Research suggests that exposure to a light flickering at 40 Hz may promote gamma-wave brain activity, which could potentially activate cells in the brain to eliminate the plaques that are common in Alzheimer's disease. They are called beta-amyloid plaques, ones that exist due to the protein build-up.
There has been testing surrounding the development of a light-sensitive molecule called a photo-oxygenation catalyst that's injected into live mice with Alzheimer's disease. Researchers have shown that while the catalyst remains mostly inactive as it rests in the cells, it activates when hit with near-infrared light. This light therapy treatment has been used by researchers on mice brains for 30 minutes each day for one week, and significant reductions have been observed in the amyloid proteins. According to the study, they successfully disrupted the amyloid structures by changing the chemical bonds holding them together.
Now that the protein has been disrupted, after destabilizing the plaque, the body’s immune system takes over and clears away the damaged cells. The researchers saw a phase occurring in mouse cells growing in a dish. The brain’s immune system enveloped the oxygenated amyloids and broke them down in acidic compartments.
Another recent investigation featured in Neuron shows that boosting gamma oscillations can improve the connection between nerve cells, reduce inflammation, and preserve against cell death in mouse models of Alzheimer’s. It also shows that the treatment's far-reaching effects involve nerve cells, or neurons, and a type of immune cell called microglia.
The researchers also examined gene changes in the treated and untreated mice. They found that the nerve cells of untreated mice had reduced activity in genes that repair DNA and in those that help operate the connections between nerve cells. The treated mice, on the other hand, showed greater activity in these genes. The treated mice had also been seen making more connections between nerve cells, and that these connections operated more coherently.
Through technological advancement, light therapy is making tremendous leaps forward in helping people with Alzheimer’s. To learn more about the benefits of light therapy on other degenerative diseases, head to our blog. If you’re interested in learning more about the power of light therapy in your own life or for your business, please reach out to our team – we look forward to connecting.
Written by the best, for the best.
Losing our memory is something we all fear of. Alzheimer's disease is a very difficult, and the most common form of dementia. This general term refers to the loss of memory and other intellectual skills so severe that it interferes with daily life. Alzheimer's disease accounts for 50-80% of dementia cases.
Alzheimer's is a neurological disorder believed to have genetic components. It's thought to be caused by the abnormal build-up of proteins in and around brain cells; and Alzheimer's is not just a disease of old age, as it was once widely believed to be. Up to 5% of people suffering from this disease have an early onset of Alzheimer's disease (also known as "early-onset"), which often appears when a person is between forty and fifty years old.
It is a life-altering disease and can be extremely challenging. It's not something that affects only the patient; it is a disease that alters the lives of those around you, as well.
The life expectancy after diagnosis is typically eight to ten years. Of course, this varies; a person can live up to 20 years post-diagnosis. Sometimes people don't get diagnosed for a few years, thus leading them to have less time.
When Alzheimer's disease strikes, it initially presents symptoms that may be so mild that they go unnoticed by both the patient and his family; however, as the disease progresses, these symptoms become more evident and begin to interfere with daily activities and relationships.
The main symptoms are significant memory loss, difficulties in producing and understanding language, inability to recognize people, objects, or places, decoding external stimuli, and difficulty performing simple voluntary movements, such as using objects. As the disease progresses, psychiatric symptoms often occur, such as depression, anxiety, apathy, irritability, and even aggression.
A person with Alzheimer's needs a safe place and environment. Things must be kept simple, and their life significantly changes. You can't really expect a person suffering from this disorder to be the same. Their personality and behavioral changes are entirely normal.
The list of light therapy uses and benefits goes on and on, as it is a form of treatment that can help with many health issues and disorders. However, for people with Alzheimer's, it can have a powerful effect on their experience.
Red light therapy is a form of therapy that works simply by producing light. There are many different devices, lightboxes, masks, and lamps that are used. The ultraviolet rays you receive in a light therapy session are the ones who directly target at the cellular level. Once the cells are penetrated by light, they accelerate at their reproductive level, increasing ATP production. ATP is the powerhouse of the mitochondria, essential for our system to function optimally.
A review of red light therapy is something we can all benefit from. There are no downsides to red light therapy, as it is a non-invasive and non-pharmaceutical procedure.
Light therapy focuses on the cellular level. MRI imaging uncovered a 61% reduction in whole-brain atrophy and losses of volume in areas associated with Alzheimer's from red light therapy treatments. It works by rejuvenating the cells, creating new ones at a higher rate. Our organism benefits from cellular alteration because of the production of new cells. This means they're not only fresh cells, but they're stronger than before.
Light therapy masks help suppress Beta-amyloid (Aβ) build-up, the protein that forms senile plaques in the brains of people with Alzheimer's and dementia. So it's focusing on getting rid of the root of the problem. With a reduced build-up, our brain cells return to their natural state, the protein having been successfully eradicated.
Kaiyan specializes in light therapy devices that are MDASAP-certified and FDA-approved, making our product easy and accessible, perfect for at-home treatments – even for some of the most challenging diseases and health conditions. Contact our team for more information.
As humans, we are made of energy and fueled by light. While nutrition and exercise play a role in our well-being and health, light plays a crucial role in us functioning optimally. New and groundbreaking research is unearthing a new understanding of how our cells function and the evidence points to the power of light.
Through technological advancements in science, it’s discovered that our bodies operate similar to a battery. Wavelengths of light give us power, while our overall health determines our ability to receive and maintain the energy from light. And this is where light therapy comes into the equation.
Science has proven that our bodies interact with specific wavelengths that benefit our bodies in various ways.
Red light therapy devices, such as light therapy masks, shine red and near-infrared light onto the skin, stimulating the production of adenosine triphosphate (ATP) within the mitochondria. By stimulating ATP, damaged cells heal, and new cells are produced faster than normal. But we’ll talk more about that in-depth a little later.
Red light therapy comprises both red light and infrared wavelengths, penetrating through the skin’s layers, right into the cells. Red light wavelengths boost collagen and elastin and improve cell communication. It penetrates superficially and helps aid various skin conditions.
Near-infrared wavelengths stimulate healing, increase mitochondrial function, and improve blood flow and tissue oxygenation. Near-infrared wavelengths penetrate deeply into the body.
At the core of your body’s healing capabilities are the mitochondria. The mitochondria play a vital role in your internal organs and tissue, including the liver, skin, heart, and muscles. It’s in charge of the body’s energy supply via ATP (adenosine triphosphate).
With both working together, they provide energy to our body and maintain the cell cycle and growth. This is why you’ll often hear the mitochondria referred to as the “powerhouse of the cell.”
Here's how the mitochondria is affected by red light:
Interestingly, our body weight is made of 70% water, with 99% of our bodies' molecules also made of water, making it a powerful component in red light therapy treatment.
Research by Prof Gerald Pollock of the University of Washington proved that water adjacent to a cell is structured water, also known as EZ water. This specific water forms a separation of charge, functioning in the body as positive and negative poles - similar to a battery.
While we’ve been talking about red light therapy, what does it actually mean? Typically, “red light therapy” refers to natural light treatments which deliver red and near-infrared wavelengths as natural sunlight using LEDs or cold lasers.
While you may think red light therapy includes all colors of light, it doesn’t. The term doesn’t include blue or white light, and it isn’t equivalent to full-spectrum light. Red light therapy doesn’t rely on heat, differentiating it from other light-based treatments such as infrared saunas and heat therapy.
Red light therapy is also known as RLT, photobiomodulation (PBM), phototherapy, LED therapy, LED light therapy, infrared therapy, low-level laser therapy, or low-level light therapy (LLLT).
As stated before, red light therapy works to heal the entire body and functions on multiple levels.
Red light therapy affects the body in multiple ways, including bodily systems:
Fascia
Fascia is the thin casing of connective tissue that surrounds virtually every organ, muscle, nerve fiber, blood vessel, and bone in place. While it performs as an internal structure for your body, the fascia also contains nerves, making it almost as sensitive as skin.
The fascia may look like a layer of tissue; however, it’s made up of interwoven layers of collagen and elastin fibers. The fascia is overlooked, yet over recent years, it has been the key to understanding how changes in one area of our body affect others. Red light therapy works to improve communication within the fascia network.
Gut-Brain Axis
The gut-brain axis connects the emotional and cognitive centers of the brain with peripheral intestinal functions. Recent research discovered the importance of gut microbiota concerning these interactions.
Red light therapy can positively influence mood and neuropsychological issues by the following:
Immune System
Red and near-infrared light penetrate through the skin into the cells, which results in low-dose metabolic stress that strengthens the cells’ anti-inflammatory and natural defense systems. In turn, the body becomes resilient to infections.
Safe and low exposure to red light therapy improves the body’s response to external viruses and bacteria. Red light therapy can influence the immune response in the following ways:
Circulatory System
Red light therapy is scientifically proven to increase the micro-circulation of blood and support the circulatory system as a whole by stimulating the development of new capillaries which carry oxygen throughout the body.
Proper oxygen supply and flow are essential for the proliferation of cells, protein synthesis, tissue restoration, inflammatory response, and angiogenesis. In addition, circulation is also responsible for waste elimination, specifically degenerated cells.
Nervous System
The nervous system includes the brain, spinal cord, neurons, and neural support cells, which is your body’s command center. It controls your movements, automatic responses, and other body systems such as digestion and breathing.
Red light therapy affects the nervous system in the following ways:
For all forms of nerve damage, red light therapy offers non-pharmaceutical treatment options.
Stem Cells
Red light therapy shows impressive results regarding stem cell growth, maximizing the potential of stem cell implantation for various medical needs. Therefore, red light therapy may show positive results after surgery to stimulate stem cells which repair tissues and organs.
In studies, red light therapy has proven to stimulate mesenchymal stem cells in bone marrow, enhancing their ability to reach the brain. This research shows the possibilities of using red light therapy to heal degenerative conditions, including Alzheimer’s, Parkinson’s disease, and dementia.
It’s clear red light therapy provides multilevel treatment to the body, becoming a popular natural and holistic option for both professionals and consumers, but where did it come from?
Light therapy technology isn’t new; it’s been around for decades as NASA experimented with red light therapy during the 1980s and 1990s. Over the past 10-20 years, red light therapy reached a breakthrough in LED lighting technology, allowing the production of safe and affordable clinical and at-home devices.
In 2016, Kaiyan Medical became the first leading manufacturer of red light therapy of affordable FDA-approved and MDASAP-approved light therapy devices.
We mentioned red light therapy being a holistic treatment option, but what does that mean. Holistic medicine is a full-body approach to healthcare. By focusing on the body, mind, and soul, the body receives the full support and care it needs to function optimally.
Principles of Holistic Medicine
Holistic medicine is based on the following principles:
The purpose of treatment is to identify the underlying cause of the disease, rather than treating only the symptoms.
While there are endless benefits the body receives from red light therapy, here are the six main benefits.
Photobiomodulation, in other words, red light therapy, has proven effective against carpal tunnel syndrome, mucositis, neck pain, menstrual cramps, temporomandibular joint pain, and neuropathic pain from amputation. It also significantly reduces the pain of hypersensitivity while improving sensorimotor function.
These improvements come after anti-inflammatory cells populate the injured area, providing long-lasting pain relief. In addition, it’s also been shown to provide effective relief by affecting the following:
Red light therapy has proven to be highly effective in rapidly treating wounds from burns, scars, bedsores, ulcers, surgery incisions, and diabetic neuropathy.
NASA strongly supports this claim as this technology was used in treating wounds. Red and near-infrared light proves effective in all four phases of the wound-healing process:
These processes are regulated by various factors connected via nitric oxide (NO) signaling release, adjusted by light energy.
An issue the body encounters when trying to heal a wound is low oxygen flow, and red light increases the flow of oxygen, speeding up the natural healing process. By reducing inflammation and increasing oxygenation of the wounded area, blood vessels can form, rapidly repairing the area, lessening pain and scarring.
By reducing pain, red light therapy eliminates the reliant on pharmaceutical painkillers during the healing process.
The human body receives energy on the cellular level, maintaining communication between organs and ensuring disease resistance.
A strong immune system works to protect the body from harmful bacteria and viruses at all times. With red light therapy, the body receives a boost of support as it releases nitric oxide and melatonin, two components involved in DNA repair and antimicrobial.
This process is called hormesis. Red and near-infrared wavelengths penetrate through the skin into the cells, causing mild metabolic stress, which stimulates cells to activate their anti-inflammatory and antioxidant response.
With the support of red light therapy, the body is better prepared to fight infections. Numerous studies have proven red light therapy to have the following effects on the immune system:
Inflammation in the body can be acute and topical (short-term, resulting from sprains, infections, and accidents) or chronic and general (long-term, caused by ongoing conditions).
Acute inflammation is a healthy bodily response; however, chronic and general inflammation can negatively impact long-term health.
As of today, the current treatment for inflammation is NSAID or steroid drugs, both having a detrimental effect on the healing process and long-term health. Red light therapy stimulates the body to activate its natural healing mechanism, reducing the health risks of long-term drug use.
Red light therapy decreases the number of inflammatory cells, increases fibroblast proliferation (cells that synthesize collagen and other matrix macromolecules), stimulates angiogenesis (creation of new blood vessels), and activates the body’s anti-inflammatory, antioxidant response.
The following conditions are connected with chronic and acute inflammation, all proving promising results with red light therapy treatment:
Red light therapy is extremely popular in competitive sports and performance. It offers natural and non-pharmaceutical treatment, which applies to many areas of the body.
Aside from the overwhelming benefits on overall health, red light therapy encourages muscles growth and repair by stimulating the production of ATP, which aids in faster recovery and better performance.
Red light therapy used before training prepares and strengthens the body while aiding muscle recovery after training.
Here are the scientifically documented effects of red light therapy:
Seasonal affective disorder (SAD) is a form of depressions, impacting 5% of Americans, specifically during the winter when there’s less natural sunlight. SAD is also known as seasonal depression or winter blues.
Many people treat SAD symptoms via bright white light treatment, mimicking the sun’s light daily. However, researchers recommend natural light treatment, like red light therapy, to help with light deficiency. Over recent years, physicians recommend red light therapy alongside psychotherapy and medication.
While many people are using red light therapy devices for at-home treatment, red light therapy systems are found in many clinical and professional settings:
Skincare Professionals: Red light therapy is a popular skincare treatment among Hollywood celebrities, including Kourtney Kardashian, Julia Roberts, and Emma Stone. Leading skincare professionals like dermatologists and aestheticians use red light therapy to help promote collagen production, reduce wrinkles, and treat skin conditions.
Health Practitioners: Health practitioners from all specialties are incorporating red light therapy into their practice. Dentists use it to reduce inflammation, physicians for mental health conditions, and oncologists for cancer side effects.
Natural Health Experts: Leading voices in the health and wellness industry such as Dr. Sarah Ballantyne, Ben Greenfield, and Dave Asprey strongly support the use of red light therapy. Paleo and Keto health experts like Robb Wolf, Mark Sisson, Luke Story, and Dr. Anthony Gustin also support red light therapy.
Sports Medicine Pros: The National Sports Association of Sports Medicine (NASM) adopted red light therapy to treat sports injuries. Top trainers and doctors, including Dr. Troy Van Biezen and Dr. Ara Suppiah, use red light therapy to heal their athletes.
Elite Pro Athletes: Professional athletes worldwide, including NFL stars like Patrick Peterson, UFC champion Anthony Pettis, and gold medal gymnast Sanne Weavers use red light therapy to enhance performance and quicken recovery.
Fitness & Training: World-renown fitness trainers, including Lacey Stone and Jorge Cruise, use red light therapy to enhance athletic performance and muscle recovery.
Supportive Cancer Care: The Multinational Association of Supportive Care in Cancer (MASCC) recommends the treatment of red light therapy for oral mucositis (OM), a common symptom of cancer treatment.
Klepeis N., Nelson W., Ott W., Robinson J., Tsang A., Switzer P., Behar J., Hern S., Engelmann W. “The National Human Activity Pattern Survey (NHAPS): a resource for assessing exposure to environmental pollutants”. Journal of Exposure Analysis and Environmental Epidemiology 2001.
Hamblin M. “Mechanisms and applications of the anti-inflammatory effects of photobiomodulation.” AIMS Biophys. 2017.
LED Lights Used in Plant Growth Experiments for Deep Space Missions. NASA.
Gál P, Stausholm MB, et al. Should open excisions and sutured incisions be treated differently? A review and meta-analysis of animal wound models following low-level laser therapy. Lasers in Medical Science. 2018 Aug.
John Foley, David B Vasily, et al. 830 nm light-emitting diode (led) phototherapy significantly reduced return-to-play in injured university athletes: a pilot study. Laser Therapy. 2016 Mar.
Kim HK, Choi JH. Effects of radiofrequency, electroacupuncture, and low-level laser therapy on the wrinkles and moisture content of the forehead, eyes, and cheek. Journal of Physical Therapy Science. 2017 February.
Wunsch A and Matuschka K. A Controlled Trial to Determine the Efficacy of Red and Near-Infrared Light Treatment in Patient Satisfaction, Reduction of Fine Lines, Wrinkles, Skin Roughness, and Intradermal Collagen Density Increase. Photomedicine and Laser Surgery. Feb 2014.
Barolet D, Roberge CJ, et al. Regulation of skin collagen metabolism in vitro using a pulsed 660 nm LED light source: clinical correlation with a single-blinded study. Journal of Investigative Dermatology. 2009 December.
Morita T., Tokura H. “ Effects of lights of different color temperature on the nocturnal changes in core temperature and melatonin in humans” Journal of Physiological Anthropology. 1996, Sept.
Naeser M., Zafonte R, Krengel MH, Martin PI, Frazier J, Hamblin MR, Knight JA, Meehan WP, Baker EH. “Significant improvements in cognitive performance post-transcranial, red/near-infrared light-emitting diode treatments in chronic, mild traumatic brain injury: open-protocol study” Journal of Neurotrauma. 2014, June.
Liu KH, Liu D, et al. “Comparative effectiveness of low-level laser therapy for adult androgenic alopecia: a system review and meta-analysis of randomized controlled trials.” Lasers in Medical Science. 2019 Aug.
Gupta AK, Mays RR, et al. “Efficacy of non-surgical treatments for androgenetic alopecia: a systematic review and network meta-analysis.” JEADV. 2018 Dec.
Afifi L, Maranda EL, et al. “Low-level laser therapy as a treatment for androgenetic alopecia.” Lasers in Surgery and Medicine. 2017 Jan.
Hofling DB, Chavantes MC, et al. Low-level laser in the treatment of patients with hypothyroidism induced by chronic autoimmune thyroiditis: a randomized, placebo-controlled clinical trial. Lasers in Surgery and Medicine. May 2013.
Hofling DB, Chavantes MC, et al. Assessment of the effects of low-level laser therapy on the thyroid vascularization of patients with autoimmune hypothyroidism by color Doppler ultrasound. ISRN Endocrinology. 2012.
Hofling DB, Chavantes MC, et al. Low-level laser therapy in chronic autoimmune thyroiditis: a pilot study. Lasers in Surgery and Medicine. 2010 Aug.
Vladimirovich Moskvin S., Ivanovich Apolikhin O. Effectiveness of low level laser therapy for treating male infertility. Biomedicine (Taipei). 2018 June.
Ban Frangez H., Frangez I., Verdenik I., Jansa V., Virant Klun I. Photobiomodulation with light-emitting diodes improves sperm motility in men with asthenozoospermia. Laser in Medical Science, 2015 Jan.
Salman Yazdi, R., Bakhshi, S., Jannat Alipoor, F. et al. Effect of 830-nm diode laser irradiation on human sperm motility. Lasers Med Sci. 2014.
Chow KW, Preece D, Burns MW. Effect of red light on optically trapped spermatozoa. Biomedical Optics Express. 2017 Aug.
Preece D., Chow KW, Gomez-Godinez V., Gustafson K., et al. Red light improves spermatozoa motility and does not induce oxidative DNA damage. Scientific Reports. 2017 Apr.
American Psychiatric Association
Cassano P, Petrie SR, et al. Transcranial Photobiomodulation for the Treatment of Major Depressive Disorder. The ELATED-2 Pilot Trial. Photomedicine and Laser Surgery. 2018 October.
Barrett DW, et al. Transcranial infrared laser stimulation produces beneficial cognitive and emotional effects in humans. 2013 Jan.
Blanco NJ, Maddox WT, Gonzalez-Lima F. Improving executive function using transcranial infrared laser stimulation. Journal of Neuropsychology. 2017 Mar.
Paolillo FR, Borghi-Silva A, et al. New treatment of cellulite with infrared-LED illumination applied during high-intensity treadmill training. J Cosmet Laser Ther. 2011 Aug;13(4):166-71.
Caruso-Davis MK, Guillot TS, Podichetty VK, Mashtalir N, Dhurandhar NV, Dubuisson O, Yu Y. Efficacy of low-level laser therapy for body contouring and spot fat reduction. Obes Surg. 2011. Jun;21(6):722-9.
Jackson RF, Dedo DD, Roche GC, et al. Low-level laser therapy as a non-invasive approach for body contouring: a randomized, controlled study. Lasers in Surgery and Medicine. Dec 2009;41(10):99-809.
McRae E and Boris J. Independent evaluation of low-level laser therapy at 635 nm for non-invasive body contouring of the waist, hips, and thighs. Lasers in Surgery and Medicine. Jan 2013.
Avci P, Gupta A, et al. Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring. Seminars in Cutaneous Medicine and Surgery. Mar 2013; 32(1): 41-52.